Simultaneous determination of 14 rodenticides in pathological material by HPLC-MS/MS after purification by solid-phase extraction
Abstract
A method for determination of rodenticides in pathological material by high-performance liquid chromatography-tandem mass spectrometry is proposed. Various sample preparation methods were compared in the course of developing the methodology. As a result of the comparison, a method that includes liquid extraction using methanol and further purification of the extract by solid-phase extraction on C18 sorbent was selected. The developed technique was validated, the detection limits were 2–5 μg/kg. The relative standard deviation of the analysis results does not exceed 20 %. The matrix effects in the determination did not exceed 25 %.
Fields of Study & Subjects
Forensic Toxicology and Drug Analysis
Pesticide Residue Analysis and Safety
Analytical chemistry methods development
Publication details
- Journal / source
- Analitika i kontrolʹ
- Volume
- 29
- Issue
- 4
- Pages
- 334–344
- Publication date
- 31 January 2026
- Language
- EN