Ischemic cardiomyopathy is characterized by insufficient proinflammatory and proangiogenic myocardial response associated with a blood HIF‑1/2 imbalance

Aim . To identify the role of impaired production of hypoxia-inducible factors (HIF) 1 and 2 in determining the balance of angiogenesis mediators, pro- and antiinflammatory cytokines in peripheral and coronary sinus blood in patients with coronary artery disease (CAD), with and without ischemic cardiomyopathy (ICM). Material and methods . The study included 30 patients with coronary artery disease (CAD) and non-cardiomyopathy, 22 patients with CAD without cardiomyopathy, and 20 healthy donors. Patients with non-cardiomyopathy had a lower left ventricular ejection fraction (LVEF) compared to CAD patients without cardiomyopathy (30,00 [22,00; 36,00]% and 59,50 [50,25; 67,00]%, p