Noninvasive markers of acute infarct-related artery occlusion in patients with non-ST-segment elevation myocardial infarction

Aim. To study noninvasive markers associated with acute infarct-related artery (IRA) occlusion in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Material and methods. We retrospectively analyzed the case records of 309 patients treated for NSTEMI between April 2021 and February 2023 at the regional vascular center of the Odintsovo Regional Hospital. All patients underwent examinations in accordance with current clinical guidelines. Results. Depending on the antegrade flow parameters in IRA, patients were divided into 2 following groups: group 1-68 patients with IRA occlusion, group 2-241 patients with slow or normal antegrade blood flow. A history of exertional angina was reported by 14,7% (n=10) of patients in group 1 and 27,8% (n=67) of patients in group 2 (p=0,028). In patients with IRA occlusion, lateral location and akinesia of the involved area were more often established (p≤0,01). In patients of group 1, high leukocyte (10,3±2,7*10 9 /l vs 8,8±2,7*10 9 /l), myocardial-specific isoenzyme creatine phosphokinase (MB-CPK) (44,4±23,8 IU/l vs 24,0±10,6 IU/l) and troponin I upon admission (122±12,9 ng/ml vs 30,3±3,1 ng/ml), (p