A meta-analysis of the literature evaluating the impact of vitamin D on female fertility and ovarian reserve function

OBJECTIVE: The current analysis study aims to estimate the role of vitamin D levels and supplementation on fertility reservation expressed as ovulation rate, pregnancy rate, and anti-Müllerian hormone (AMH). METHOD: A systematic literature review was conducted, and 2111 females were recruited to the current study. Inclusion criteria of the current study included comparative studies evaluating the role of vitamin D status and vitamin D supplementation on fertility parameters. Included studies published till December 2023. Continuous mode with random effect, were used for the analysis of data. RESULTS: Twenty-two studies, conducted on the impact of vitamin D on fertility parameters for females, were recruited in the current study. Vitamin D supplementation showed a significant enhancement in several parameters, including vitamin D level, number of dominant follicles, Ovulation rate, and pregnancy rate (MD = -2.3295% CI [-3.07, -1.56], MD = 0.81 95% CI [0.27, 1.35], MD = 0.81 95% CI [0.17, 1.45], and MD = 0.64 95% CI [0.20, 1.07], respectively). On the other hand, there was no significant impact on AMH levels. CONCLUSION: Findings of current studies indicate a beneficial impact of vitamin D therapy on fertility outcomes regarding the number of dominant follicles, ovulation rate, and pregnancy rate.