Relationship between triglyceride-glucose index and risk of acute myocardial infarction in patients with atrial fibrillation

ObjectiveTo explore the relationship between triglyceride-glucose (TyG) index and the occurrence of acute myocardial infarction (AMI) in patients with atrial fibrillation (AF). MethodsA total of 4 277 hospitalized AF patients from Beijing Tongren Hospital and Beijing Friendship Hospital affiliated to Capital Medical University were enrolled. They were divided into a non-AMI group [AMI(−), 3 725 cases] and an AMI group [AMI(+), 552 cases] based on whether they were admitted for AMI. Logistic regression was used to assess the association between the TyG index and AMI, and subgroup analyses were performed according to the presence of diabetes at baseline. ResultsAmong AF patients, the TyG index was significantly higher in the AMI(+) group than in the AMI(−) group (8.83 ± 0.73 vs. 8.56 ± 0.66, P < 0.001). Additionally, patients in the AMI(+) group were older and had more comorbidities (both P < 0.05). Multivariate Logistic regression showed that high TyG index was an independent risk factor for AMI in AF patients [odds ratio(OR) = 1.824, 95%CI 1.540−2.161, P < 0.001], and the area under the receiver operating characteristic (ROC) curve for the TyG index in predicting AMI was 0.614 (95%CI 0.589−0.640, P < 0.001), with a cut-off value of 8.79. In AF patients, the TyG index was positively associated with the risk of AMI regardless of the presence of diabetes. ConclusionsThe TyG index is positively associated with the risk of AMI in AF patients, which is not affected by diabetes status.