Research progress on neutrophil extracellular traps in sepsis-induced acute respiratory distress syndrome

Neutrophil extracellular traps(NETs) are networks made of chromatin fibers released from polymorph nuclear neutrophils, mainly composed of DNA, histones and granule proteins. NETs are able to mediate downstream signaling pathways, which can activate inflammatory responses, leading to lung tissue injury. And can activate the coagulation pathway, promote microthrombus formation, lead to microcirculation disorders, and further aggravate the damage of lung tissue. These mechanisms of action revealed that NETs are risk factors for sepsis-induced acute respiratory distress syndrome(ARDS) progression, and that inhibition of the release of NETs has an important role in the mechanisms of delaying ARDS progression.