Evaluation of Myonectin and Irisin Levels in Pregnant and Non-Pregnant Women

Objective: To compare serum myonectin and irisin levels between healthy pregnant and non-pregnant women, and to evaluate their relationship with metabolic parameters.Materials and Methods: We conducted a cross-sectional study including 40 pregnant women in their second trimester (between 14 and 28 weeks of gestation) (case group) and 45 healthy non-pregnant women (control group). Fasting blood samples were analyzed for myonectin, irisin, glucose, insulin, and lipid profile. Myonectin and irisin were measured by ELISA. Statistical analyses were performed using SPSS v28, with group comparisons by t-test/Mann–Whitney U, correlations by Spearman’s rho, and diagnostic performance by receiver operating characteristic (ROC) curves.Results: Pregnant women had significantly lower fasting glucose but higher total cholesterol, triglycerides, LDL-C, and HDL-C levels than controls (p