Clinical and Instrumental Study for the Evaluation of the Efficacy of the Regimen with Endocare Renewal Glycoperfect Serum and Creamy Cleanser in Patients with Facial Photoaging

Background: Alpha Hydroxyacids (AHAs) stimulate epidermal renewal and secondarily promote cell regeneration. Different studies have suggested the Antiaging Power of Glycolic acid (GA) via several complementary mechanisms which facilitate cutaneous regeneration while diminishing agerelated changes. Methods: An open-label, prospective clinical study was conducted in 20 Latina women aged 30–55 years presenting moderate wrinkles and hyperpigmented lesions (≥ 3 on the Rao-Goldman scale). The Glycoperfect treatment protocol lasted 60 days and consisted of morning cleansing with a Creamy Cleanser, daily photoprotection, and nighttime application of an Intensive Serum. The serum was used every other night during the first week and if no irritation was observed then nightly thereafter. All formulations were based on high concentration of Glycolic Acid (GA), azelaic acid encapsulated in nanovesicles and soothing ingredients. Clinical evaluations were scheduled at baseline (T0), 30 days (T30), and 60 days (T60). Instrumental assessments measured hydration, elasticity, firmness, radiance, pore characteristics, wrinkle parameters, roughness, and pigmentation contrast. A dermatologist also performed clinical evaluations, including tolerability, while participants completed a self-assessment questionnaire. Results: At day 60, significant improvements were observed. Skin hydration increased by 45.8 ± 14.9%, and elasticity improved by 8.5 ± 2.3% (p