Corn silk composite tea bag: formulation and bioactivity

Hyperuricemia (HUA) is a common metabolic disorder characterized by abnormal purine metabolism (Subbu et al., 2025).Chronic HUA not only leads to gout but is also closely associated with various complications, including kidney damage, hypertension, cardiovascular diseases, and diabetes, which significantly impair patients' quality of life (Park et al., 2020; Yu and Cheng, 2020).Currently, allopurinol may cause liver dysfunction and hematologic toxicity, febuxostat carries potential cardiovascular risks, and benzbromarone has been associated with hepatotoxicity (Du et al., 2024).Consequently, the development of natural products for lowering uric acid with high safety and minimal side effects has become a major focus of research.Natural plants, rich in bioactive compounds, have demonstrated significant potential in the prevention and management of metabolic disorders (Li et al.,