Sacral stimulation and multisensor colonic motility recording in minipigs v1

2026 Preprint Open access

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Authors: Muriel H. Larauche, Alex Baldwin, Sahar Elyahoodayan, Victor Pikov, Xinghao Huang, Mona Mohamed, Hangbo Zhao, Maral P. S. Mousavi, Ellis Meng, Million Mulugeta
DOI: 10.17504/protocols.io.36wgq14pxvk5/v1
Cited by: 1

Abstract

This protocol describes acute experiments involving sacral stimulation of minipigs while monitoring distal colon motility. Stimulation at various amplitudes and frequencies is applied to the S2 or S3 sacral roots using a bipolar cuff. Colon motility is monitored using multiple sensing modalities including electromyography (EMG), colon wall strain sensing, intraluminal pressure manometry, and electrochemical dopamine sensing.

Fields of Study & Subjects

Gastrointestinal motility and disorders Congenital gastrointestinal and neural anomalies Vagus Nerve Stimulation Research

Publication details

Publisher
Springer Science and Business Media LLC
Publication date
6 January 2026
Document type
Preprint