Approach to spatially profile free modifed nucleic acid metabolites through DNA RNA Elements Areal Mass Spectrometry (DREAMS) v1

2026 Preprint Open access

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Authors: Yan Peng, Liang Xue, Magdalena J. Koziol
DOI: 10.17504/protocols.io.5qpvoj54bg4o/v1
Cited by: 1

Abstract

DNA RNA Elements Areal Mass Spectrometry (DREAMS) entails directing a spray solution at a moving biological sample to release metabolites. The liberated modified nucleic acid metabolites are then detected by MS and spatially visualized for comprehensive sample analysis.

Fields of Study & Subjects

Mass Spectrometry Techniques and Applications Molecular Biology Techniques and Applications DNA and Nucleic Acid Chemistry

Publication details

Publisher
Springer Science and Business Media LLC
Publication date
22 June 2026
Document type
Preprint