Profile of interleukin for differential diagnosis of sepsis and other diagnoses in neonates. v1

Neonatal sepsis constitutes a life threatening condition with very few decisive diagnostic methods. The authors aim with this review is to map and synthesize the existing evidence on the use of cytokines as biomarkers for the differential diagnosis of neonatal sepsis and other clinical conditions in newborns. The review will systematically identify the types of biomarkers studied, their diagnostic accuracy, and the clinical contexts in which they have been applied. The expected results include a comprehensive overview of the cytokines most frequently evaluated for neonatal sepsis, their reported diagnostic performance, and the gaps in current evidence. With these findings, the authors aim to inform clinical practice and guide future research on inflammatory biomarkers in neonatal care.