Methodological Approach for Screening and Evaluation of Literature using the Rayyan Tool v1

This protocol describes a process for use of Rayyan to screen published literature. The technique is embedded into a framework based on PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses). The open source Rayyan tool may be used on a mobile device, tablet or as a web application to screen literature based on title and abstract. In this protocol, we describe a method for gamification of Rayyan screening for rapid and efficient systematic literature reviews. The complete process as described in Koscelny et al, (2026) it is shown in Figure 1, with the key steps utilizing the Rayyan Tool illuminated in red.