Impact of central sensitization on peripheral treatment outcomes in chronic pain patients: a systematic review and meta-analysis

This study explores the impact of central sensitization on chronic pain treatment outcomes, considering intervention types, assessment methods, and follow-up duration. It examines the association between central sensitization and post-treatment pain severity and overall health, while accounting for factors such as pain type and measurement techniques. Moderator analyses provide insight into how these variables influence treatment response, offering guidance for optimizing therapeutic strategies and clinical expectations.