Chronobiological Entrainment as a Primary Modality for Endocrine Homeostasis: The "Circadian Fortress" Hypothesis

The modern digital and nutritional environment is characterized by ubiquitous artificial light and continuous, erratic caloric intake. This environmental architecture induces chronic circadian misalignment, which is increasingly recognized as a foundational driver of metabolic syndrome, neuroinflammation, and autonomic nervous system dysregulation. Current standard-of-care interventions prioritize macronutrient manipulation and thermodynamic energy balance, frequently failing to address the upstream temporal inputs governing metabolic pathways.