The Systematic Engine: A Conceptual Framework for Transparent Critical Appraisal in Evidence Synthesis

This project presents the Systematic Engine, a novel conceptual model that reframes critical appraisal from a procedural checkpoint into the central, dynamic process that powers transparent evidence synthesis. The framework comprises four integrated functions: (1) Deconstruction & Profiling, (2) Stratification & Weighting, (3) Certainty Calibration via GRADE, and (4) Interpretive Guarding. This registration includes the complete methodological framework, implementation guidelines, and resources for applying the Systematic Engine in systematic reviews across clinical, preclinical, and social science domains.