Psychiatric symptoms and syndromes in gliomas: a systematic review

This systematic review summarizes evidence on the prevalence, evolution, and clinical correlates of psychiatric symptoms in adults with glioma. By synthesizing findings from 129 eligible studies, it shows that depression and anxiety are the most common and clinically significant syndromes, with distinct temporal patterns across the disease course. The review also highlights their associations with survival, functional outcomes, and quality of life, describes the rare occurrence of psychotic features, and outlines preliminary neuroanatomical links. Overall, the study underscores psychiatric morbidity as a core component of glioma and calls for routine assessment and targeted interventions.