Nitric Oxide Dysregulation as a Driver of Vascular Complications in Sickle Cell Disease: A Scoping Review

Significance This research provides a comprehensive synthesis of mechanistic and clinical evidence linking hemolysis, NO dysregulation, and vascular disease in SCD. It offers a framework for understanding genotype-specific risk, informs clinical management and public health strategies in high-burden regions, and guides future research and therapeutic interventions. Timeline Activity Duration Literature search & screening 2 months Data extraction 1 month Data synthesis & analysis 1 month Drafting manuscript & conceptual framework 1 month Review & finalization 1 month Dissemination Plan Publication in peer-reviewed journals Presentations at hematology, cardiovascular, and public health conferences Policy briefs for SCD management in West Africa Funding No external funding received