Probiotic Supplementation Effect on Glycemic Parameter and Pro-inflammatory Marker in Prediabetic Patient: A Systematic Review and Meta-Analysis

Prediabetes remains the main risk factors for diabetes progression in the world. The available therapy aimed at lifestyle modification such as diet or physical activity for prediabetes. The interest in gut microbiome modification such as probiotics supplementation has been progressing rapidly for chronic non communicable early intervention. The evidence regarding efficacy and and safety for prediabetes population lacking. This systematic review and meta analysis aimed at evaluating published randomized controlled trials on probiotics supplementation studies evaluating glycemic parameter and pro-inflammatory marker in prediabetic patient. The outcome in this review are glycemic parameter (HbA1C, glycated albumin, fasting plasma glucose, 2 hour post prandial glucose) and pro-inflammatory marker (IL-6 and TNF-a)