Oral microbiota changes associated with early childhood caries revealed through next-generation sequencing: A scoping review

This scoping review will summarize the current evidence on the association between oral microbiota features and early childhood caries (ECC) in preschool children, with a focus on findings derived from next-generation sequencing (NGS) technologies. It is expected to reveal difference in alpha diversity, beta diversity and discriminative species of the microbial community between caries-free and ECC-affected preschool children.