Patient and Healthcare Provider Preferences for Respiratory Vaccine Attributes: A Targeted Literature Review of Influenza, COVID-19, and RSV

The landscape of adult immunization is evolving rapidly with the co-circulation of Influenza, COVID-19, and Respiratory Syncytial Virus (RSV), making the understanding of vaccine decision-making a public health priority. This targeted literature review (TLR) aims to systematically identify and synthesize stated-preference data to quantify the trade-offs patients and healthcare providers (HCPs) make regarding seasonal respiratory vaccines. By focusing specifically on choice-based conjoint methodologies, such as Discrete Choice Experiments (DCEs) and Best-Worst Scaling (BWS), this research moves beyond simple attitude assessments to reveal the relative importance of specific vaccine attributes like efficacy, safety, and logistical convenience. To ensure high methodological rigor and efficiency, the study employs a technology-enhanced approach, utilizing an AI-assisted screening workflow (AIscreenR) with strict human-in-the-loop quality control. The anticipated outcomes include a standardized hierarchy of attributes across the three disease areas and an analysis of the "preference gap" between prescribers and recipients. Ultimately, this work provides an evidence-based roadmap for public health communicators and developers to tailor immunization programs and messaging, with the goal of increasing vaccine coverage and addressing stakeholder-specific concerns in the seasonal respiratory landscape.