Decussation of neural pathways in vertebrates: a scoping review of explanatory theories

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Authors: Bárbara de Paula Ferreira, Sara Edith Souza de Assis Leão, Nathálya Gardênia de Holanda Marinho Nogueira
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Abstract

This project consists of a scoping review aimed at mapping and analyzing the main theoretical models that explain the decussation of neural pathways and the contralateral organization of the central nervous system in vertebrates. Although this organizational pattern is one of the pillars of neuroscience, its evolutionary origins and functional significance remain under debate. The review will follow the PRISMA-ScR guidelines and the Joanna Briggs Institute recommendations, using the PCC strategy (Population: vertebrates; Concept: neural pathway decussation; Context: explanatory theoretical models). Reviews and theoretical studies published in English will be included, with no temporal restrictions, and searches will be conducted in the PubMed, Scopus, and Web of Science databases. The study is expected to historically organize the proposed theories, identify convergences and explanatory gaps, and contribute to a more integrated understanding of contralateral organization in the vertebrate nervous system.

Fields of Study & Subjects

Neurogenesis and neuroplasticity mechanisms Hemispheric Asymmetry in Neuroscience Neurology and Historical Studies

Publication details

Publication date
1 January 2026
Document type
Preprint