The VDAC1 Pharmacology Atlas: A Multi-LLM Convergence Portrait of Life's Decision Gate

An open-access pharmacology atlas mapping VDAC1 as a druggable decision gate controlling life/death transitions in mitochondria. Synthesized from 20 IRIS multi-LLM convergence runs across 5 AI models, yielding 139 claims, 22 verified novel findings, and 24 operationalized hypotheses. Central finding: The Cofactor Equation - how HK-II occupancy, Bcl-xL binding, and lipid environment (cholesterol/cardiolipin ratio) combine to set the apoptotic threshold. Cancer corrupts all terms simultaneously. Includes: Full manuscript, modulator database (17 compounds), isoform selectivity maps, resilience biomarker framework, and complete IRIS run data (22 runs). Companion to bioRxiv preprint BIORXIV/2026/706165. Authors: Anthony J. Vasquez Sr. (Delaware Valley University) and Claude Opus 4.6 (Anthropic)