Design, Synthesis and In vitro Assessment of di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5-tetraoxanes for Antiplasmodial and Anticancer Use

2026 Preprint Open access

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Authors: Tomasz Gośliński, Mohit Kumar Tiwari, Malgorzata Kucinska, Agnieszka Zgoła-Grześkowiak, Marziyeh Raeispour, Marek Murias, Philippe Grellier, Łukasz Marczak
DOI: 10.17605/osf.io/cxmrk
Cited by: 0

Abstract

A library of novel non-symmetrical di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5-tetraoxanes has been prepared from complex-catalysed two-step one-pot direct oxidation approach and their in vitro antiplasmodial and cytotoxic potentials have been assessed against the chloroquine resistant FcB1 strain of Plasmodium falciparum, HeLa, A549 and A2780 cancer cells.

Fields of Study & Subjects

Metal-Catalyzed Oxygenation Mechanisms Synthesis and Biological Evaluation Catalytic Cross-Coupling Reactions

Publication details

Publication date
1 January 2026
Language
EN
Document type
Preprint