Serotonergic Modulation in Rodent Acute Pancreatitis: Systematic Review of Psychotropic and Psychotropic-Like Interventions

This project is a systematic synthesis of in vivo rodent studies testing whether psychotropic and serotonergic interventions modify the severity and outcomes of experimentally induced acute pancreatitis. Its purpose is to identify which pharmacological nodes have been evaluated, how consistently they affect pancreatic injury readouts (biochemistry, histopathology) and severe-disease endpoints (including mortality where reported), and to distinguish defensible target-level mechanisms from unsupported drug-repurposing claims. The evidence is organized by recurring mechanistic classes: serotonergic signalling with emphasis on the 5-HT2/5-HT2A receptor node; broader neuroimmune/stress-related serotonergic modulation (including 5-HT3-linked and SERT-oriented interventions where studied); and cell-intrinsic stress pathways such as oxidative stress/ferroptosis, where some clinically used psychotropics have been proposed to exert protection via redox mechanisms. A key feature is explicit translational constraint: interpretation is benchmarked against human pharmacoepidemiological meta-analyses reporting pancreatitis risk signals for SSRIs and/or antipsychotics, to prevent overclaiming clinical benefit or safety from preclinical findings. Expected outputs are a PRISMA-traceable workflow (search strings, screening log, extraction sheet), a concise mechanism-oriented synthesis, a transparent limitations/risk-of-bias appraisal, and concrete recommendations for future experimental designs to improve reproducibility and translation.