Interventions for Cancer-Related Cognitive Impairment in Breast and Gynecologic Cancers: A Systematic Review and Meta-Analysis

Cancer-related cognitive impairment (CRCI) is a prevalent and clinically meaningful survivorship concern among individuals treated for breast and gynecologic cancers. CRCI can involve difficulties in attention, memory, processing speed, and executive functioning, and it is often accompanied by distress and functional disruption. Although a range of nonpharmacologic (e.g., cognitive rehabilitation, physical activity, mindfulness-based programs) and pharmacologic interventions have been evaluated, the comparative effectiveness of these approaches, particularly across breast and gynecologic cancer populations, remains incompletely synthesized.