Nano- and Microstructured Delivery Systems Containing Diphenyl Diselenide: A Scoping Review

Diphenyl diselenide, an organoselenium compound widely investigated in experimental models, exhibits several pharmacological properties, including antioxidant, anti-inflammatory, neuroprotective, antimicrobial, and antitumor activities. Despite its promising biological potential, the therapeutic application of this compound may be limited by toxicity, bioavailability, and targeted delivery. In this context, nano- and microstructured drug delivery systems have emerged as promising strategies to enhance the pharmacological performance of bioactive compounds. These systems can enhance compound stability, enable controlled release, improve drug delivery, and reduce adverse effects. This scoping review aims to map the scientific literature on the use of diphenyl diselenide incorporated into nano- and microstructured systems, identifying the types of formulations developed, their applications, and the main biological effects reported. The review will be conducted following the methodology proposed by the Joanna Briggs Institute for scoping reviews and reported in accordance with the PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. Searches will be performed in the PubMed, Scopus, and Web of Science databases using terms related to diphenyl diselenide and nano- and microstructured delivery systems. The findings are expected to provide a comprehensive overview of current research on nano- and microformulations containing diphenyl diselenide, highlighting the main formulation strategies, therapeutic applications, and gaps for future investigations