ADAPT (Adaptive Digital Approaches to Well-Being Promotion Trial): A three-armed randomized controlled trial evaluating the efficacy of two personalized, transdiagnostic mental health products

With increasing levels of psychological distress, low-threshold apps and programs are the first option for users to receive support. However, most apps are not evidence-based. To close this gap, the two online programs HelloBetter MindFIT and Ello are introduced as personalized, adaptive interventions to support users in coping with stress and increasing general well-being. HelloBetter MindFIT is an online and modular program that uses machine learning models to recommend evidence-based exercises to each user. Ello comprises an LLM-based chatbot specifically built for mental well-being support. The ADAPT study is a randomized controlled trial (RCT) to evaluate both programs’ efficacy compared to a no-intervention (NI) control group. The primary hypothesis is that both programs reduce users’ stress experience (measured with PSS-10) significantly better compared to a NI control group. Secondary endpoints include psychological well-being, self-efficacy, as well as depressive and anxiety problems. Additionally, safety, usage behavior and satisfaction are examined. The study utilizes a parallel design with single-blinding. Adults with good German skills (min. C1) and without acute suicidality are eligible to participate. The study includes a baseline measurement, a post-assessment after 6 weeks and an uncontrolled follow-up after 3 months.