Two-Level Bioenergetic Coherence Model Integrating NAD⁺, ROS, and ATP within the ISHEA Δ±1 Framework

Aquí tienes una descripción breve, estilo Wikipedia (neutral y enciclopédica): --- The ISHEA Δ±1 Two-Level Bioenergetic Coherence Model is a theoretical mathematical framework that conceptualizes cellular metabolism as a two-layered system integrating redox regulation and energy execution. The model proposes that NAD⁺-dependent redox balance and regulated reactive oxygen species (ROS) signaling form an upstream informational-regulatory layer, while adenosine triphosphate (ATP) functions as a downstream energetic execution layer. Within the ISHEA Δ±1 framework, systemic bioenergetic states are represented using a bounded nonlinear coherence metric ranging from −1 to +1. The model incorporates weighted contributions and interaction terms between normalized biological variables and uses computational sensitivity analyses to evaluate parameter influence. It is presented as a systems biology approach to modeling bioenergetic organization and does not constitute a clinically validated diagnostic tool.