Meta-Analytic Trial Re-Investigation exercise

This registration documents the pre-specified statistical analysis plan for the MATRIX study (Meta-Analytic Trial Re-Investigation eXercise), version 2.0, dated March 2026. Data extraction has not been initiated at the time of this registration. The complete SAP is attached as a file to this registration. Any amendment to the analysis plan after the start of data extraction will be documented as a new registration version with a changelog.