Quantifying insula neurotransmitter concentrations in misophonia and non-misophonic clinical emotion dysregulation: an in-vivo spectroscopy study

Misophonia is a disorder of decreased tolerance to sounds and associated stimuli that often causes significant emotional distress. This study will examine whether in-vivo concentrations of the main excitatory (glutamate) and inhibitory (GABA) neurotransmitters as measured by proton magnetic resonance spectroscopy (1H-MRS) within the left and right insula are associated with misophonia symptoms in adults, as well as the therapeutic response to non-invasive neurostimulation (repetitive transcranial magnetic stimulation [rTMS]).