Adhesive Bonding to Dentin Under Conditions Associated with Advanced Glycation End Product Accumulation: A Scoping Review

This scoping review aims to map and synthesize the existing evidence on the bonding performance of dental adhesive and ionomer-based restorative systems to dentin substrates affected by conditions associated with advanced glycation end product (AGE) accumulation, including diabetes mellitus, natural ageing, and experimentally induced glycation. Guided by the Population–Concept–Context (PCC) framework and conducted in accordance with Joanna Briggs Institute methodology and the PRISMA-ScR reporting guidelines, the review systematically explores in vitro, ex vivo, preclinical, and clinical studies that evaluate adhesive outcomes on AGE-modified dentin. The outcomes of interest include bond strength, interfacial morphology, microleakage, mineral content, and remineralization. A comprehensive literature search was performed across PubMed, Scopus, Web of Science, and Embase from database inception to December 1, 2025, with no language or date restrictions. Two reviewers independently screened studies, extracted data, and synthesized findings descriptively. The review seeks to characterize the extent, nature, and methodological diversity of current research, identify trends in adhesive performance across diabetic, aged, and glycated dentin substrates, and highlight key knowledge gaps, particularly the lack of direct quantification of dentin AGE levels and limited data on remineralization and long-term durability. The findings are intended to inform future experimental design, guide clinical adhesive strategies for compromised dentin substrates, and support the development of more robust bonding approaches for ageing and diabetic populations.