Mapping Subdural Hematoma Membrane Biology to Patient Outcomes and Radiological Features: A Scoping Review

Subdural hematoma (SDH) membranes are recognized as central drivers of hematoma persistence and recurrence. While the cellular and molecular features of these membranes have been characterized, this biological evidence has not been systematically mapped to clinical outcomes or radiological features. This scoping review addresses the existing gap between microscopic membrane biology and macroscopic clinical manifestations. Following the PRISMA-ScR framework, this review will search MEDLINE, Embase, PsycInfo, Scopus, Web of Science, and CINAHL to identify primary studies of adult human SDH membranes. Primary Objective: To map associations between cellular/molecular membrane findings and patient-centered outcomes (e.g., recurrence, mortality, functional status) or CT-derived radiological features (e.g., density, internal architecture). Secondary Objective: To integrate findings with currently proposed pathogenic mechanisms to contextualize biological and clinical significance.