CSF/Serum pTau181 Dissociation Pattern Distinguishes Peripheral vs CNS Tau Sources: Predictions for ALS, AD, and Diagnostic Accuracy

2026 Preprint Open access

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Authors: Arthur Stewart
DOI: 10.17605/osf.io/mvwqh
Cited by: 0

Abstract

Primary Prediction: The ratio of CSF pTau181 to serum pTau181 distinguishes peripheral tau elevation (muscle/injury) from CNS tau pathology, with specific patterns predicting cognitive outcomes.

Fields of Study & Subjects

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Amyotrophic Lateral Sclerosis Research

Publication details

Publication date
1 January 2026
Language
EN
Document type
Preprint