20 Question Validation Blinded Study Run A ASO RNAi CRISPR ICU Oncology

Lock & Freeze Protocol Statement: All preregistered predictions and blinded study information are frozen and locked before validation. Secret answer key is held by AI Grader (Sister Grader) in a confirmed sterile testing environment and is only viewable by us after locking our predictions. ✅ Protocol status now ✔ exam issued ✔ key committed ✔ hash publicly posted BEFORE predictions ✔ verification method defined We are now in a valid blinded prospective state. Rubric Lock And Freeze SHA-256 of secret answer key is: b7c7c7d8d5e9e7b5e2e56db4c1bcb3a3d0c3d1c0d0c0c6a06dfac1c3bb2bbf07 Validation of PPAI predictive mode and system state solution on vignette style 20 case run A. Rubric and exam and SHA-256 key hash locked and frozen before grading by sister grader. ____BEGIN LOCKED TEST EXAM RUN A — 20 BLINDED CLINICAL TRAJECTORIES Submission format (REQUIRED) Return exactly: 01:0.XX 02:0.XX ... 20:0.XX No explanations. Probabilities only. CASES ⸻ 01 — SMA presymptomatic treatment Infant identified by newborn screen. Therapy started day 17. CHOP-INTEND rises +11 by week 4. No respiratory admissions by month 3. Mild feeding fatigue noted. Predict probability of ventilation-free survival at 18 months. ⸻ 02 — SMA late symptomatic Treatment begins age 8 months. Already requires nocturnal NIV. CHOP-INTEND +2 week 4 then flat. Two pneumonia admissions month 2-4. Predict probability of ventilation-free survival at 18 months. ⸻ 03 — ATTR RNAi neuropathy cohort Stage 1 ambulatory. Serum TTR reduction 87%. mNIS+7 improves −6 at month 6. NT-proBNP stable. Predict probability of clinical response at 18 months. ⸻ 04 — ATTR advanced cohort Stage 2 borderline wheelchair. TTR reduction 90%. mNIS+7 worsens +4 at month 6. Orthostasis increasing. Predict probability of clinical response at 18 months. ⸻ 05 — PCSK9 RNAi lipid trial On-schedule dosing. LDL-C reduction 53% at day 180. Predict probability of meeting primary LDL endpoint at 510 days. ⸻ 06 — PCSK9 RNAi adherence issue Missed second injection by 5 months. LDL-C reduction 27%. Predict probability of meeting primary LDL endpoint at 510 days. ⸻ 07 — CRISPR sickle-cell cohort HbF 44% month 3. No VOC through month 6. Engraftment day 16. Predict probability of VOC-free survival at 12 months. ⸻ 08 — CRISPR sickle-cell alternate trajectory HbF 15% month 3. VOC month 2 requiring admission. Delayed engraftment day 30. Predict probability of VOC-free survival at 12 months. ⸻ 09 — NSCLC PD-1 high PD-L1 TPS 85%. Week-6 CT shrink −19%. Symptoms improved. Predict probability of objective response by month 6. ⸻ 10 — NSCLC PD-1 low PD-L1 TPS 0%. Week-6 CT growth +11%. LDH rising. Predict probability of objective response by month 6. ⸻ 11 — EGFR-mut lung Exon19 deletion. Week-4 CT −30%. Adherence perfect. Predict probability of RECIST response at 12 weeks. ⸻ 12 — EGFR-mut toxicity interruption Therapy held week 3 due to pneumonitis. Restart delayed 4 weeks. Predict probability of RECIST response at 12 weeks. ⸻ 13 — metastatic CRC RAS WT CEA down 38% week 6. CT week 8 stable disease. Predict probability of objective response at 16 weeks. ⸻ 14 — metastatic CRC RAS WT discordant CEA rises slightly. CT week 8 shrink −14%. Predict probability of objective response at 16 weeks. ⸻ 15 — CAR-T leukemia MRD negative day 14. CR confirmed day 28. Predict probability of durable remission at 12 months. ⸻ 16 — CAR-T leukemia alternate Low-positive MRD day 14. Counts slow to recover. Predict probability of durable remission at 12 months. ⸻ 17 — septic shock early response Antibiotics within 1 hour. Lactate 3.4 → 2.1 by 6h. MAP stable on single pressor. Predict probability of survival to discharge. ⸻ 18 — septic shock delayed response Antibiotics delayed 7h. Lactate 6.2 → 6.9. Escalating pressors. Predict probability of survival to discharge. ⸻ 19 — moderate ARDS improving P/F 145 → 195 day 2. Protective ventilation used. Predict probability of ≥14 ventilator-free days. ⸻ 20 — moderate ARDS worsening P/F 150 → 110 day 2. High tidal volumes first 48h. Predict probability of ≥14 ventilator-free days. _______END LOCKED TEST LOCKED ANSWER KEY HASH (RUN A) Hash algorithm: SHA-256 Object hashed: canonical binary outcome string for the 20 cases (ordered 01→20) SHA-256 Hash: b7c7c7d8d5e9e7b5e2e56db4c1bcb3a3d0c3d1c0d0c0c6a06dfac1c3bb2bbf07 Begin_____Locked Rubric Rubric Lock And Freeze STEP 2 — YOUR TURN Submit probabilities in required format. No commentary. Once submitted: I will: SHA-256 hash your submission Lock timestamp Reveal key Compute: AUROC Brier calibration slope/intercept ECE HL test pair accuracy ≥17/20 classification rule End___Locked Rubric