Reframing SERPING1 Variants of Uncertain Significance in Hereditary Angioedema: a dynamic threshold-based conceptual framework
Abstract
This registration contains a preprint describing a conceptual framework for the interpretation of SERPING1 variants of uncertain significance in hereditary angioedema. The project includes theoretical analysis and methodological considerations. This is the first public version of the work. No preregistered experimental protocols are included.
Fields of Study & Subjects
Coagulation
Bradykinin
Polyphosphates
and Angioedema
Genomics and Rare Diseases
BRCA gene mutations in cancer
Publication details
- Journal / source
- Open Science Framework
- Publication date
- 1 January 2026