DENND1A-related DNA region hydroxymethylation and blood triglyceride levels: A scoping literature review

Elevated blood triglyceride levels are a common public health and clinical condition influenced by both environmental and genetic factors. A specific DNA segment of interest to us is the DENN domain-containing protein 1A (DENND1A)-related region, which is differentially expressed in normal cells and neoplasia and is strongly associated with polycystic ovary syndrome (PCOS) in women. This region is subjected to epigenetic modifications, including hydroxymethylation. The goal of this research project is to explore and synthesize previous evidence on the relationship of blood triglyceride levels to hydroxymethylation in the DENND1A-related DNA region to better understand epigenetic effects on metabolic dysregulation. This project will be conducted as a structured scoping literature review primarily following the PRISMA-Scr guideline, compiling and critically evaluating existing evidence on the epigenetic regulation of DENND1A-related DNA regions. A critical review of previous evidence is essential to understand how hydroxymethylation mechanisms may contribute to prevalent metabolic conditions and to identify research and/or knowledge gaps with potential implications for innovative clinical therapeutic and population preventive strategies.