Optimal Glucose Management Using Advanced Hybrid Systems in Type 1 Diabetes: Extended Meta-Analysis Comparing Control-IQ, Medtronic, and the iLet Bionic Pancreas.

Automated insulin delivery (AID) systems integrate continuous glucose monitoring with algorithm-driven insulin dosing to improve glycemic control in type 1 diabetes mellitus (T1DM). Hybrid closed-loop (HCL) systems such as Control-IQ and Medtronic MiniMed™ require user input, whereas the insulin-only iLet® bionic pancreas operates with a higher level of automation. Comparative evidence across these advanced systems remains limited.