Replication of Kuehn et al., 2012

In this study we aim to replicate one of the key findings from the paper by Kuehn et al. (2012, https://doi.org/10.1016/j.jad.2012.03.024) “Why ruminators won´t stop: The structural and resting state correlates of rumination and its relation to depression”. This replication is part of the overarching project “Replication of Findings in Neuroimaging – MDD” (ReFiNe-MDD, https://osf.io/n86q9/) using data from various cohorts. The project aims to a) estimate the percentage of replicable findings in brain structural gray matter correlates related to variables relevant for depression, b) identify study characteristics associated with replicability of neuroimaging findings, and c) deduct methodological guidelines to foster replicability of findings in this area of research. Therefore, a minimum of 60 single replications will be conducted. In this single replication, we will focus on the association of gray matter volume and rumination in healthy controls. Kuehn et al. (2012) found rumination to be negatively associated with clusters in bilateral inferior frontal gyrus (IFG), bilateral anterior cingulate cortex (ACC) and bilateral mid cingulate cortex (MCC) in healthy individuals. Additionally, we will examine whether this association can also be found in depressed patients.