Non-invasive spinal cord stimulation (tsDCS) in Major Depressive Disorder: A systematic review.

This project contains the protocol for a systematic review investigating the effectiveness and safety of transcutaneous spinal direct current stimulation (tsDCS) on depressive symptoms in adults. The review will include studies involving individuals diagnosed with Major Depressive Disorder as well as clinical populations in which depressive symptoms are reported as secondary outcomes. Eligible studies include randomized and non-randomized interventional studies, crossover trials, and observational studies. Searches will be conducted in PubMed, Scopus, SciELO, and ClinicalTrials.gov. The protocol is registered to ensure transparency and reproducibility of the review process.