Exosomes in Non-Surgical Aesthetic Medicine: A Scoping Review of Study Characteristics, Product Characterization, Safety, and Regulatory Compliance

This scoping review aims to systematically map the current evidence regarding the use of exosomes and extracellular vesicles (EVs) in non-surgical aesthetic medicine. Following the JBI methodology and the PRISMA-ScR guidelines, this study will evaluate the landscape of clinical research published between 2015 and 2025. The review focuses on four key objectives: Methodological Quality: To identify the study designs and clinical populations currently being researched. Technical Adherence: To assess the degree of compliance with MISEV 2023 guidelines (characterization, origin, and biomarkers). Safety and Transparency: To map reported adverse events and disclose potential conflicts of interest or funding biases. Regulatory Mapping: To analyze the alignment between clinical use and the regulatory frameworks of the AEMPS, EMA, and FDA. The expected outcome is to provide a comprehensive "evidence map" that identifies critical gaps in safety and regulation, offering a benchmark for clinicians and regulatory bodies in the field of regenerative aesthetics.