Chemical Characterization of Essential Oils from Calocedrus formosana and Cunninghamia lanceolata and Their Neuroprotective and Regenerative Effects on Human Neuroblastoma Cells

• Comprehensive Chemical Mapping: Utilizing both GC-MS and SPME to characterize tissue-specific (heartwood, bark, leaves) terpenoid profiles. • Novel Therapeutic Models: Application of three distinct bioassay models (protection, repair, and coculture) using SK-N-SH and drug-resistant SK-N-BE(2) neuroblastoma cells to simulate neuronal injury. • Key Findings: Identification of alpha-terpinolene and cedrol as potent anti-inflammatory agents, and the discovery that CF-derived limonene exhibits superior regenerative capacity compared to standard reference compounds.