Systemic inflammatory biomarkers following occupational wildfire smoke exposure in wildland firefighters: a systematic review and meta-analysis

This project contains the protocol and materials for a systematic review and meta-analysis investigating systemic inflammatory biomarker responses following occupational exposure to wildfire smoke in wildland firefighters. The review will synthesize evidence from observational and exposure studies measuring inflammatory biomarkers such as IL-6, IL-8, TNF-α, and C-reactive protein before and after wildfire smoke exposure during firefighting operations. The primary objective is to quantify acute inflammatory responses associated with wildfire smoke exposure using meta-analytic methods. The project will follow PRISMA guidelines and includes the search strategy, eligibility criteria, data extraction templates, and statistical analysis plan.