Anticholinergic Burden and Risk of Motor Vehicle Crash Injuries: A Case-Crossover Analysis

We aimed to determine whether exposure to medications with a high cumulative anticholinergic burden is associated with a significantly higher risk of motor vehicle crash injury (MVCI) as drivers or not in the general population, compared with exposure to low or no cumulative anticholinergic burden. Therefore, our objective was to conduct a retrospective longitudinal study in a claims database using a self-controlled case-crossover design to assess the association between anticholinergic burden and motor vehicle crash injury (MVCI), while adjusting for relevant confounding variables. Additionally, we will apply an exploratory data-driven method to identify the anticholinergic burden trends most likely to affect the risk for MVCIs.