Immune Resonance in Rheumatoid Arthritis — A Systems Model of T–B Cell Synchronization and Therapeutic Implications

This work presents a structural model for chronic inflammatory diseases, using rheumatoid arthritis as the primary example. The model defines disease expression as the interaction of intrinsic factors, external synchronizing stimuli, and individual susceptibility, formalized through a mathematical framework integrating immune pathways, cytokine modes, and B‑cell clonal dynamics. This framework resolves long‑standing clinical contradictions such as MTX non‑response, relapse after biologics withdrawal, and heterogeneous disease courses. The model is developed as an applied extension of a broader resonance‑based theoretical framework, adapted here to describe the structural dynamics of chronic inflammation. Although rheumatoid arthritis is used as the central case, the structure is generalizable to a wide range of chronic diseases.