Efficacy and Safety Profile of Aprocitentan in Hypertension: A Dose-Stratified Meta-Analysis of Randomized Controlled Trials

This systematic and meta-analysis examines the effect of different doses of aprocitentan on blood pressure and its safety in patients with hypertension. It compares low, medium, and higher doses to identify the dose range that achieves meaningful blood pressure reduction without excess adverse events. The analysis also summarizes treatment-emergent and serious adverse events to define the overall tolerability profile and inform the optimal dosing strategy for clinical use.