Raw and processed data supporting "Human chorionic gonadotropin decreases cerebral cystic encephalomalacia and parvalbumin interneuron degeneration in a pro-inflammatory model of mouse neonatal hypoxia-ischemia"

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Authors: Benjamin Miller, Alexander Crider, Bhooma R. Aravamuthan, Rafael Galindo
Cited by: 0

Abstract

This dataset contains histological, immunohistochemical, quantitative, and image data supporting the publication “Human chorionic gonadotropin decreases cerebral cystic encephalomalacia and parvalbumin interneuron degeneration in a pro-inflammatory model of mouse neonatal hypoxia-ischemia” in Scientific Reports. Data were generated using a lipopolysaccharide (LPS)-sensitized neonatal mouse model of hypoxia-ischemia (HI), with and without human chorionic gonadotropin (hCG) pretreatment. The dataset includes measurements of tissue loss and cystic encephalomalacia, assessments of parvalbumin (PV) interneuron integrity, and quantification of microglial Iba1 immunoreactivity, along with corresponding high-resolution histological and immunofluorescence images acquired using a NanoZoomer slide scanner. The dataset comprises raw and processed quantitative data files (CSV), high-resolution image files (TIF), and accompanying documentation organized to support reproducibility and reuse. Folder and file organization is designed to align with figures and supplemental figures in the associated publication.

Fields of Study & Subjects

Neonatal and fetal brain pathology Neuroinflammation and Neurodegeneration Mechanisms Fetal and Pediatric Neurological Disorders

Publication details

Journal / source
Mendeley Data
Publication date
13 February 2026
Language
EN
Document type
Dataset