Osteopontin-4 (OPN-4) suppresses tumor progression features whilst sensitizing c643 anaplastic thyroid cells to sorafenib

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Authors: Gabriela Ribeiro, Amanda Rubim, Flavia da Cunha Vasconcelos, Luciana Ferreira, John Greenman, Etel Rodrigues Pereira Gimba
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Abstract

This processed dataset is associated with the study “Osteopontin-4 (OPN-4) suppresses tumor progression features whilst sensitizing c643 anaplastic thyroid cells to sorafenib.” The dataset includes results from cell proliferation, viability and migration assays, cell death and cell cycle analyses, as well as experiments performed in 3D culture conditions combined with a microfluidic device. Additionally, the dataset contains data regarding the cellular response to sorafenib treatment in the context of OPN-4 expression modulation in the c643 cell line. All experiments were conducted in duplicate or triplicate, with at least three independent biological replicates. The Excel file is organized into sheets identified according to the corresponding figures presented in the article, providing essential experimental information to support data interpretation and reuse.

Fields of Study & Subjects

Bone and Dental Protein Studies Cancer Mechanisms and Therapy Cell death mechanisms and regulation

Publication details

Journal / source
Mendeley Data
Publication date
27 January 2026
Document type
Dataset