Serum proteomic profiles in keratoconus, post-laser vision correction ectasia, and pellucid marginal degeneration

This dataset accompanies the manuscript titled 'Common and distinct features in serum proteomic profiles in keratoconus, post-laser vision correction ectasia, and pellucid marginal degeneration’ by Jaskiewicz-Rajewicz et al., submitted to Investigative Ophthalmology & Visual Science (IOVS). In this study serum samples from 93 patients with keratoconus (KTCN), 10 patients with post-laser vision correction (PLVC) ectasia, 4 patients with pellucid marginal degeneration (PMD), and 44 controls were profiled using tandem matrix-assisted laser desorption/ionization time of flight/time of flight mass spectrometry (MALDI-TOF/TOF MS/MS). Clinical and environmental variables (e.g. allergy/atopy/asthma, eye rubbing intensity), together with ophthalmologic parameters (K1, K2, Kmax, TCT, anterior/posterior elevation), were assessed in the principal component analysis (PCA), Weighted Gene Co-expression Network Analysis (WGCNA), Mann–Whitney feature testing, linear modelling, and Spearman correlation and other analyses. The data was processed on 10 December 2025. Mendeley Supplementary Table 1. Table containing sample metadata, including Sample ID (short), corresponding Patient ID, study subgroup, sex, and age. Mendeley Supplementary Table 2. Table containing unprocessed m/z peak intensity values detected in analyzed spots, indexed by the corresponding Sample ID (short).