Temporal epilepsy: contribution of molecular genetics to epileptogenesis mechanisms
Abstract
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. The mechanisms of epileptogenesis in TLE involve a wide range of neurobiological, biochemical, genomic, epigenetic, and transcriptomic changes. Together, these processes lead to morphofunctional reorganization of neural networks and the onset of spontaneous seizures. Neuroinflammation (involving glia activation and cytokine release), neural network remodeling, impaired signal transmission, and loss of inhibitory interneurons play a prominent role in epileptogenesis. Hippocampus transcriptomic studies have revealed a wide range of involved genes, highlighting the importance for interplay between genetic predisposition and acquired factors in developing this disease. The review presents current views on the neurobiological and molecular genetic basis of TLE-related epileptogenesis.
Fields of Study & Subjects
Epilepsy research and treatment
Neuroscience and Neuropharmacology Research
Genetics and Neurodevelopmental Disorders
Publication details
- Journal / source
- Epilepsy and Paroxysmal Conditions
- Publisher
- IRBIS
- Volume
- 17
- Issue
- 4
- Pages
- 402–409
- Publication date
- 15 January 2026
- Language
- RU